Cic edizioni internazionali
Functional Neurology

Venous angioplasty in multiple sclerosis: neurological outcome at two years in a cohort of relapsing-remitting patients

Original Article, 55 - 59
Tag this article
Abstract
Full text HTML Full text PDF

An open study was conducted with the aim of reporting long-term clinical outcome of endovascular treatment for chronic cerebrospinal venous insufficiency (CCSVI) in patients with multiple sclerosis (MS).
Twenty-nine patients with clinically definite relapsing-remitting MS underwent percutaneous transluminal angioplasty for CCSVI, outside a clinical relapse. All the patients were regularly observed over at least two years before the first endovascular treatment and for at least two years after it (mean post-procedure follow up 30.6±6.1 months). The following clinical outcome measures were used: annual relapse rate and Expanded Disability Status Scale (EDSS) score. All the patients were observed intensively (mean 6 hours) on the day of the endovascular treatment to monitor for possible complications (bleeding, shock, heart attack, death).
We compared the annual relapse rate before and after treatment (in the two years before and the two years after the first endovascular treatment) and the EDSS score recorded two years before versus two years after the treatment.
Overall, 44 endovascular procedures were performed in the 29 patients, without complications. Thirteen of the 29 patients (45%) underwent more than one treatment session because of venous re-stenosis: 11 and two patients underwent two and three endovascular treatments respectively.
The annual relapse rate of MS was significantly lower post-procedure (0.45±0.62 vs 0.76±0.99; p=0.021), although it increased in four patients. The EDSS score two years after treatment was significantly lower compared to the EDSS score recorded at the examination two years before treatment (1.98±0.92 vs 2.27±0.93; p=0.037), although it was higher in four patients.
Endovascular treatment of concurrent CCSVI seems to be safe and repeatable and may reduce annual relapse rates and cumulative disability in patients with relapsing-remitting MS. Randomized controlled studies are needed to further assess the clinical effects of endovascular treatment of CCSVI in MS.

Vol. XXXIV (No. 2) 2019 April/June

  1. The nine circles of EBM hell
    Iosa M., Antonucci G., Paolucci S.
  2. The impact of an aquatic exercise program on BDNF levels in Parkinson’s disease patients: short-and long-term outcomes
    da Silva Germanos S., Vieira B., Reichert Vital da Silva I., da Cunha J.J., Nique S., Striebel V., Pochmann D., Rostirola Elsner V.
  3. Obstructive sleep apnea: neurocognitive and behavioral functions before and after treatment
    Turner K., Zambrelli E., Lavolpe S., Baldi C., Furia F., Canevini M.P.
  4. Risk factors and subtypes of ischemic stroke in young patients: an observational study from a teaching hospital in Saudi Arabia
    Shahid R.
  5. Wearable sensors, cerebral palsy and gait assessment in everyday environments: is it a reality? – A systematic review
    Rozin Kleiner A.F., Bellomo A., Pagnussat A.S., de Athayde Costa e Silva A., Sforza C., Cicuto Ferreira Rocha N.A.
  6. ERIGO: a possible strategy to treat orthostatic hypotension in progressive supranuclear palsy? A feasibility study
    Sorbera C., Portaro S., Cimino V., Leo A., Accorinti M., Silvestri G., Bramanti P., Naro A., Calabrò R.S.
  7. Influence of neurorehabilitation on stroke-induced modifications of the quadriceps muscle in elderly subacute stroke patients with paresis
    Ciancarelli I., Mariangeli F., Tonin P., Ciofani E., Garo M.L., Tozzi Ciancarelli M.G.
  8. Motor cortex function in fibromyalgia: a pilot study involving near-infrared spectroscopy and co-recording of laser-evoked potentials
    Gentile E., Ricci K., Delussi M., de Tommaso M.
  9. Low back pain related to a sacral insufficiency fracture: role of paravertebral oxygen-ozone therapy in a paradigmatic case of nociplastic pain
    de Sire A., Baricich A., Minetto M.A., Cisari C., Invernizzi M.
  10. Rehabilitation assisted by robotic and electromechanical devices for persons with neurological disabilities: an Italian consensus conference
    Boldrini P., Bonaiuti D., Mazzoleni S., Posteraro F.
Last Viewed articles: la lista degli ultimi x visitati.
  1. Venous angioplasty in multiple sclerosis: neurological outcome at two years in a cohort of relapsing-remitting patients
    Salvi F., Bartolomei I., Buccellato E., Galeotti R., Zamboni P.
credits