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Functional Neurology

Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study

Article, 33 - 37
doi: 10.11138/FNeur/2016.31.1.033
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Abstract
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There is growing evidence that headaches are connected to melatonin secretion. Our aim was to assess the potential effectiveness of melatonin for primary headache prevention.
Forty-nine patients (37 with migraine and 12 with chronic tension-type headache, TTH) were prescribed oral melatonin, 4 mg, 30 minutes before bedtime for six months. Forty-one (83.6%) of the 49 patients completed the study, while eight dropped out for personal reasons.
A statistically significant reduction in headache frequency was found between baseline and final follow-up after six months of treatment (p=0.033 for TTH patients and p<0.001 for migraineurs). The
Headache Impact Test score was significantly reduced in both groups of headache patients (p=0.002 and p<0.001, respectively).
At baseline, melatonin levels, measured both during a headache attack and a pain-free period, did not differ between patients with TTH and migraineurs (p=0.539 and p=0.693, respectively), and no statistically significant differences in
Hamilton Depression Rating Scale scores were found between the two groups.
Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study
This pilot study shows promising results, in terms of headache frequency reduction and daily quality of life improvement, in both groups

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  1. Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study
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    doi: 10.11138/FNeur/2016.31.1.033
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