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Functional Neurology

Diet transiently improves migraine in two twin sisters: possible role of ketogenesis?

Original Article, 305 - 308
doi: 10.11138/FNeur/2013.28.4.305
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Abstract
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The ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following lowcarbohydrate, low-calorie diets prescribed for rapid
weight loss.
We report the case of a pair of twin sisters, whose high-frequency migraine improved during a ketogenic diet they followed in order to lose weight.
The observed time-lock between ketogenesis and migraine improvement provides some insight into how ketones act to improve migraine.

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