Cic edizioni internazionali
Functional Neurology

Genes and the dynamics of pain control

Article, 9 - 15
Tag this article
Abstract
Full text HTML Full text PDF
There are well-documented sex differences in the prevalence of various painful disorders. To comprehend the mechanisms underlying these differences requires an understanding of the molecular organisation and systems biology that are responsible for the pain
experience. The pain system evolved to secure the survival of the animal under a variety of environmental constraints and needed to be flexible enough to compete against other behavioural needs and homeostatic demands. From the periphery to the cortex, mechanisms exist to facilitate or inhibit nociceptive signalling and it is this inherent plasticity that is thought to be perturbed in chronic pain states. There is limited evidence to suggest that polymorphisms or mutations in certain genes and gender can influence the pain experience but it seems likely that epigenetics and the influence of past experience are responsible for a substantial part of the variation between sexes and between individuals.

Vol. XXXIII (No. 4) 2018 October/December

  1. Music and neurorehabilitation: Yes, we can!
    Raglio A.
    doi: 10.11138/FNeur/2018.33.4.173
  2. Clinical and neuroimaging spectrum of hyperglycemia-associated chorea-ballism: systematic review and exploratory analysis of case reports
    Gómez-Ochoa S.A., Espín-Chico B.B., Pinilla-Monsalve G.D., Kaas B.M., Téllez-Mosquera L.E.
    doi: 10.11138/FNeur/2018.33.4.175
  3. Recovery of circadian melatonin rhythm after a melatonin holiday in daytime haemodialysis patients on long-term exogenous melatonin
    Sparla S., Koch B.C., Bosma R., Nagtegaal E.
    doi: 10.11138/FNeur/2018.33.4.188
  4. Multiple sclerosis and non-dystrophic myotonias: do they share a common pathophysiology?
    Portaro S., Naro A., Russo M., Bramanti P., Lauria P., D'Aleo G., La Rosa G., Bramanti A., Calabrò R.S.
    doi: 10.11138/FNeur/2018.33.4.194
  5. From paper to informatics: the Post Soft Care-App, an easy-to-use and fast tool to help therapists identify unmet needs in stroke patients
    De Bartolo D., Morone G., Lupo A., Aloise F., Baricich A., Di Francesco D., Calderone C., Cisari C., Verdecchia G., Sandrini G., Pistarini C., Antonucci G., Smania N., Paolucci S., Iosa M.
    doi: 10.11138/FNeur/2018.33.4.200
  6. Automated mechanical peripheral stimulation and postural control in subjects with Parkinson’s disease and freezing of gait: a randomized controlled trial
    Prusch J.S., Kleiner A.F.R., Salazar A.P., Pinto C., Marchese R.R., Galli M., Pagnussat A.S.
    doi: 10.11138/FNeur/2018.33.4.206
  7. Is bupropion useful in the treatment of post-stroke thalamic apathy? A case report and considerations
    Aragona B., De Luca R., Piccolo A., Le Cause M., Destro M., Casella C., Filoni S., Calabrò R.S.
    doi: 10.11138/FNeur/2018.33.4.213
  8. TIA patients with higher ABCD3-I scores are prone to a higher incidence of intracranial stenosis, unstable carotid plaques and multiple-vessel involvement
    Yu Q., Miao W., Han J.
    doi: 10.11138/FNeur/2018.33.4.217
  9. Is there a correlation between urological and cardiovascular dysfunction in Parkinson’s disease?
    Brusa L., Rocchi C., Ponzo V., Stanzione P., Finazzi E., Attanasio A.
    doi: 10.11138/FNeur/2018.33.4.225
  10. Cross-cultural adaptation and validation in the Italian population of the wolf motor function test in patients with stroke
    Berardi A., Dhrami L., Tofani M., Valente D., Sansoni J., Galeoto G.
    doi: 10.11138/FNeur/2018.33.4.229
  11. The dawn of algometry: Paolo Mantegazza’s research on pain
    Cani V.
    doi: 10.11138/FNeur/2018.33.4.254
Last Viewed articles: la lista degli ultimi x visitati.
  1. Genes and the dynamics of pain control
    Hunt S.P.
credits