Cic edizioni internazionali
Functional Neurology

The relationship between anaerobic lactate threshold and plasma catecholamines during incremental exercise in hereditary spastic paraplegia.

Original Article, 83 - 87
Tag this article
Abstract
Full text HTML Full text PDF
Lower limb muscle chronic hyperactivity in hereditary spastic paraplegia (HSP) is the consequence of motor corticospinal tract involvement, which in turn has been hypothesized to be of mitochondrial origin. In order to assess skeletal muscle aerobic metabolism and sympathetic response during exercise in 10 HSP patients, we evaluated their blood lactate and catecholamine levels during an incremental workload bicycle exercise.
Lactate, but not epinephrine or norepinephrine, levels were significantly higher in the HSP patients than in control subjects, in both resting conditions and during exercise. In the patients, the anaerobic lactate threshold was reached prematurely (at 50% of the predicted normal maximal power output) when compared to normal controls. This finding was not related to any specific muscle morphology or histochemical activity. Although other factors, including chronic spasticity and muscle deconditioning, have to be considered in the interpretation of our data, our results suggest the possible involvement of a mitochondrial mechanism, independently of sympathetic system overactivation, in exercising skeletal muscle of HSP patients.

Vol. XXXII (No. 4) 2017 October/December

  1. Volunteering in hospitals to improve the quality of long stays in rehabilitation units
    Barbieri M., Maffoni M., Negro S., Maddalena D., Bosone D., Tronconi L.
    doi: 10.11138/FNeur/2017.32.4.171
  2. Neurophysiology of the pelvic floor in clinical practice: a systematic literature review
    Bianchi F., Squintani G.M., Osio M., Morini A., Bana C., Ardolino G., Barbrieri S., Bertolasi L., Caramelli R., Cogiamanian F., Currà A., de Scisciolo G., Foresti C., Frasca V., Frasson E., Inghilleri M., Maderna L., Motti L., Onesti E., Romano M.C., Del Carro U.
    doi: 10.11138/FNeur/2017.32.4.173
  3. The usefulness of sLORETA in evaluating the effect of high-dose ARA-C on brain connectivity in patients with acute myeloid leukemia: an exploratory study
    Zarabla A., Ungania S., Cacciatore A., Maialetti A., Petreri G., Mengarelli A., Spadea A., Marchesi F., Renzi D., Gumenyuk S., Strigari L., Maschio M.
    doi: 10.11138/FNeur/2017.32.4.195
  4. Apathy in corticobasal degeneration: possible parietal involvement
    Moretti R., Caberlotto R., Signori R.
    doi: 10.11138/FNeur/2017.32.4.201
  5. Foreground and background: an interview with Peter Singer and three arguments against naturalism
    Loffi A.
    doi: 10.11138/FNeur/2017.32.4.211
  6. Add-on perampanel and aggressive behaviour in severe drug-resistant focal epilepsies
    Juhl S., Rubboli G.
  7. The culturally adapted Italian version of the Barthel Index (IcaBI): assessment of structural validity, inter-rater reliability and responsiveness to clinically relevant improvements in patients admitted to inpatient rehabilitation centers
    Castiglia S.F., Galeoto G., Lauta A., Palumbo A., Tirinelli F., Viselli F., Santilli V., Sacchetti M.L.
    doi: 10.11138/FNeur/2017.32.4.221
  8. The need for better access to pain treatment: learning from drug consumption trends in the USA
    Scuteri D., Piro B., Morrone L.A., Corasaniti M.T., Vulnera M., Bagetta G.
    doi: 10.11138/FNeur/2017.32.4.229
Last Viewed articles: la lista degli ultimi x visitati.
  1. The relationship between anaerobic lactate threshold and plasma catecholamines during incremental exercise in hereditary spastic paraplegia.
    Siciliano G., Pasquali L., Manca M.L., Del Corona A., Tessa A., Patrono C., Prontera C., Zucchelli G., Santorelli F.M.
credits